The neonatal splice variant of Nav1.5 potentiates in vitro invasive behaviour...
AbstractUpregulation of functional voltage-gated Na+ channels (VGSCs) occurs in metastatic human breast cancer (BCa) in vitro and in vivo. The present study aimed to ascertain the specific involvement...
View ArticleTherapeutic potential for phenytoin: targeting Na v 1.5 sodium channels to...
AbstractVoltage-gated Na+ channels (VGSCs) are heteromeric membrane protein complexes containing pore-forming α subunits and smaller, non-pore-forming β subunits. VGSCs are classically expressed in...
View ArticleThe sodium channel-blocking antiepileptic drug phenytoin inhibits breast...
AbstractBackgroundVoltage-gated Na+ channels (VGSCs) are heteromeric protein complexes containing pore-forming α subunits and smaller, non-pore-forming β subunits. VGSCs are classically expressed in...
View ArticleMetastatic breast cancer cells induce altered microglial morphology and...
AbstractBackgroundAn emerging problem in the treatment of breast cancer is the increasing incidence of metastases to the brain. Metastatic brain tumours are incurable and can cause epileptic seizures...
View ArticleTargeting Ion Channels for Cancer Treatment: Current Progress and Future...
AbstractIon channels are key regulators of cancer cell pathophysiology. They contribute to a variety of processes such as maintenance of cellular osmolarity and membrane potential, motility (via...
View ArticleSodium channel-inhibiting drugs and survival of breast, colon and prostate...
AbstractMetastasis is the leading cause of cancer-related deaths. Voltage-gated sodium channels (VGSCs) regulate invasion and metastasis. Several VGSC-inhibiting drugs reduce metastasis in murine...
View ArticleInhibition of N1-Src kinase by a specific SH3 peptide ligand reveals a role...
AbstractIn the mammalian brain the ubiquitous tyrosine kinase, C-Src, undergoes splicing to insert short sequences in the SH3 domain to yield N1- and N2-Src. We and others have previously shown that...
View ArticleVoltage-Gated Calcium Channels as Key Regulators of Cancer Progression
AbstractCalcium (Ca2+) is a universal and versatile second messenger regulating everything from cell growth to cell death. As a result, Ca2+ regulates many processes that are hallmarks of cancer, such...
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